CAR appeals for French help against rebels, Paris balks


BANGUI (Reuters) - The president of the Central African Republic appealed on Thursday for France and the United States to help push back rebels threatening his government and the capital, but Paris said its troops were only ready to protect French nationals.


The exchanges came as regional African leaders tried to broker a ceasefire deal and as rebels said they had temporarily halted their advance on Bangui, the capital, to allow talks to take place.


Insurgents on motorbikes and in pickup trucks have driven to within 75 km (47 miles) of Bangui after weeks of fighting, threatening to end President Francois Bozize's nearly 10-year-stint in charge of the turbulent, resource-rich country.


French nuclear energy group Areva mines the Bakouma uranium deposit in the CAR's south - France's biggest commercial interest in its former colony.


The rebel advance has highlighted the instability of a country that has remained poor since independence from Paris in 1960 despite rich deposits of uranium, gold and diamonds. Average income is barely over $2 a day.


Bozize on Thursday appealed for French and U.S. military support to stop the SELEKA rebel coalition, which has promised to overthrow him unless he implements a previous peace deal in full.


He told a crowd of anti-rebel protesters in the riverside capital that he had asked Paris and Washington to help move the rebels away from the capital to clear the way for peace talks which regional leaders say could be held soon in Libreville, Gabon.


"We are asking our cousins the French and the United States, which are major powers, to help us push back the rebels to their initial positions in a way that will permit talks in Libreville to resolve this crisis," Bozize said.


France has 250 soldiers in its landlocked former colony as part of a peacekeeping mission and Paris in the past has ousted or propped up governments - including by using air strikes to defend Bozize against rebels in 2006.


But French President Francois Hollande poured cold water on the latest request for help.


"If we have a presence, it's not to protect a regime, it's to protect our nationals and our interests and in no way to intervene in the internal business of a country, in this case the Central African Republic," Hollande said on the sidelines of a visit to a wholesale food market outside Paris.


"Those days are over," he said.


Some 1,200 French nationals live in the CAR, mostly in the capital, according to the French Foreign Ministry, where they typically work for mining firms or aid groups.


CEASEFIRE TALKS


The U.N. Security Council issued a statement saying its members "condemn the continued attacks on several towns perpetrated by the 'SELEKA' coalition of armed groups which gravely undermine the Libreville Comprehensive Peace Agreement and threaten the civilian population."


U.S. State Department spokesman Patrick Ventrell said the U.S. embassy had temporarily suspended operations and the U.S. ambassador and other embassy personnel had left the country.


Officials from around central Africa are due to meet in Bangui later on Thursday to open initial talks with the government and rebels.


A rebel spokesman said fighters had temporarily halted their advance to allow dialogue.


"We will not enter Bangui," Colonel Djouma Narkoyo, the rebel spokesman, told Reuters by telephone.


Previous rebel promises to stop advancing have been broken, and a diplomatic source said rebels had taken up positions around Bangui on Thursday, effectively surrounding it.


The atmosphere remained tense in the city the day after anti-rebel protests broke out, and residents were stocking up on food and water.


Government soldiers deployed at strategic sites and French troops reinforced security at the French embassy after protesters threw rocks at the building on Wednesday.


In Paris, the French Foreign Ministry said protecting foreigners and embassies was the responsibility of the CAR authorities.


"This message will once again be stressed to the CAR's charge d'affaires in Paris, who has been summoned this afternoon," a ministry spokesman said.


He also said France condemned the rebels for pursuing hostilities and urged all sides to commit to talks.


Bozize came to power in a 2003 rebellion that overthrew President Ange-Felix Patasse.


However, France is increasingly reluctant to directly intervene in conflicts in its former colonies. Since coming to power in May, Hollande has promised to end its shadowy relations with former colonies and put ties on a healthier footing.


A military source and an aid worker said the rebels had got as far as Damara, 75 km (47 miles) from Bangui, by late afternoon on Wednesday, having skirted Sibut, where some 150 Chadian soldiers had earlier been deployed to try and block a push south by a rebel coalition.


With a government that holds little sway outside the capital, some parts of the country have long endured the consequences of conflicts in troubled neighbors Chad, Sudan and the Democratic Republic of Congo spilling over.


The Central African Republic is one of a number of nations in the region where U.S. Special Forces are helping local forces try to track down the Lords Resistance Army, a rebel group responsible for killing thousands of civilians across four African nations.


(Additional reporting by Leigh Thomas and Louis Charbonneau; Writing by Richard Valdmanis; Editing by Andrew Osborn and Paul Simao)



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Football: Bosses on notice as owners eye Premier promotion






LONDON: Henning Berg, sacked by Blackburn after just 57 days, and Sean O'Driscoll, dismissed by Nottingham Forest just six months into his reign, became the latest managers to discover that patience is an increasingly rare quality among chairmen chasing the dream of a lucrative place in the Premier League.

Owen Coyle, booted out by Bolton in October after a slow start to the season, and Paul Jewell, fired by Ipswich with a relegation battle looming, had already been losers in the Championship's frantic game of managerial musical chairs.

There have been eight bosses on the move with only half the season gone and more casualties are certain to follow in the new year.

And, as ever in modern day football, money is the root cause of the blood-letting.

The rewards of promotion are estimated at around £90 million, but the cost is even greater for the managers who fall short of that goal.

The prospect of buying a sleeping giant and turning them into a cash cow has convinced a series of investors from across the world to pitch up at second-tier clubs with a wad of cash and promises of instant success.

But when that seductive talk of promotion falters on the pitch, there is no apology from the owners for spreading false hope. Instead it is the managers who are made the scapegoats.

Nowhere is that more apparent than at Blackburn, where Indian owners Venky's are searching for their third manager of the season following the brutal dismissal of Berg on Thursday.

Berg, who played in the Blackburn team that won the Premier League in 1995, had been appointed as successor to the much-criticised Steve Kean, who avoided the sack despite relegation from the top-flight last season but then quit in September amid suggestions Venky's were meddling in his team selections.

Although Berg had won only one of his first 10 matches -- a 1-0 defeat on Wednesday to Middlesbrough was their fifth loss in six matches -- he surely deserved longer to get a troubled club back on an even keel.

In the circumstances, it was hardly surprising that the Norwegian should talk of being "bitterly disappointed" at his treatment.

Manchester United defender Rio Ferdinand summed up the disbelief felt by the football world when he tweeted: "Henning Berg was given loads of time to implement his coaching ideas and get the team playing the way he wanted, 50 something days... NOT!!

"Berg didn't even get to see a transfer window let alone take part in one?!?"

While O'Driscoll was given a little longer than Berg by Forest's Kuwaiti owners, he still had plenty of cause for complaint.

Forest were just one point outside the play-off places after a 4-2 win over Leeds on Wednesday, yet even that wasn't good enough for impatient Kuwaiti chairman Fawaz Al Hasawi, who talked of the need for a manager with Premier League experience after sacking O'Driscoll, widely regarded as one of the most astute managers in the lower divisions.

Danny Collins, one of O'Driscoll's first signings when he took charge at Forest in July, said: "To hear the news that the gaffer had gone was obviously a surprise, and we're shocked and disappointed at the same time."

Forest striker Simon Cox added on Twitter: "So we win 4-2 and the manager gets the sack. Gutted for Sean, pleasure to work under. Wonder who will walk through the door next."

And as the stakes get even higher in the coming months, there will be plenty more managers and players nervously wondering when the next change will come.

The pressure will be most intense for under-achieving Wolves boss Stale Solbakken, Malky Mackay at leaders Cardiff, where the Malaysian owners are determined to secure promotion at all costs, and Nigel Pearson at Leicester, whose Thai owners have been spent big to reach the top-flight.

- AFP/al



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Autonomy founder fires back at HP after news of DOJ inquiry



Autonomy founder Mike Lynch



(Credit:
HP)


Autonomy founder and former CEO Mike Lynch is firing back at Hewlett-Packard after the release of HP's annual report with the U.S. Securities and Exchange Commission today. The report states that the federal government opened an inquiry into HP's acquisition of Autonomy in November and hints that Autonomy's accounting is partially to blame.

"It is extremely disappointing that HP has again failed to provide a detailed calculation of its $5 billion write-down of Autonomy, or publish any explanation of the serious allegations it has made against the former management team, in its annual report filing today," Lynch said in an e-mailed statement. "Furthermore, it is now less clear how much of the $5 billion write-down is in fact being attributed to the alleged accounting issues, and how much to other changes in business performance and earnings projections."

HP acquired the enterprise software company in August 2011 for $11.1 billion, or 11 times its annual earnings. Since the purchase, controversy, lawsuits, and an $8.8 billion charge against HP's earnings have ensued.

HP and Lynch have traded arguments in the press over who deserves the blame for Autonomy's subpar performance. In its fourth-quarter earnings release last month, HP said it had discovered "extensive evidence" of fraudulent accounting and failed disclosures on Autonomy's part leading up to the sale. Consequently, Lynch set up a Web site that denies HP's charges and says HP mishandled the company after acquiring it.

"We also do not understand why HP is raising these issues now given that Autonomy reported into the HP Finance team from the day the acquisition completed in October 2011, there was an extensive due diligence process and Autonomy was audited as a public company for many years," Lynch said today. "We also note the statement in HP's annual report that it received confirmation from the U.S. Department of Justice on 21 November 2012 (the day after HP's first public statement), that the Department had opened an investigation. We can confirm that we have as yet had no contact from any regulatory authority. We will co-operate with any investigation and look forward to the opportunity to explain our position."


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Classes delayed for Sandy Hook Elementary kids

NEWTOWN, Conn. The children at the Sandy Hook Elementary school won't be returning to classes for another week, but officials from the town, school district and local agencies are doing their best in the meantime to keep them occupied following a massacre at their school two weeks ago.

The students have not attended school since a gunman killed 20 of their schoolmates and six adults on Dec. 14. They are slated to return to a different school next Thursday.

In the meantime, they've been treated to field trips, toy giveaways and some organized play time.

"A couple of the teachers have done pizza parties," said Janet Robinson, Newtown's school superintendent. "Another met her kids at the library so they could have a little reading time together. The most important thing has been connecting the students back to their teacher and their classmates."




Play Video


Newtown schools superintendent: We have to move forward






39 Photos


Victims of Conn. school shooting






Play Video


Newtown police get a break on Christmas



The Newtown Youth Academy, a nonprofit sports center, opened its doors to all kids in town at no cost shortly after the shooting. But from 9 a.m. to 2 p.m. last week, the building's turf field, basketball and tennis courts, and giant inflatable obstacle course were reserved just for Sandy Hook Elementary students.

There have been arts and crafts for the smaller kids, as well as face-paintings. Some celebrities, including two members of the Harlem Globetrotters and former University of Connecticut basketball star Tina Charles, also have stopped by to play with the children.

UConn's men's basketball team and its coaches made a trip to the academy Thursday and played games with the kids, posed for photos and signed autographs. "It was great for us to be able to see some smiles on their faces and to spend some time with them," Coach Kevin Ollie said.

On Thursday afternoon, school buses were loading up at the Youth Academy for a trip to Stamford and a larger complex, Chelsea Piers, which also has ice rinks and an indoor swimming pool, said academy owner Peter D'Amico. Sports celebrities, such as Brooklyn Nets forward Kris Humphries, planned to meet them there.

"The idea was to get them away from the house, the television and all the coverage of this tragedy and get them to a place where kids can just be kids," said D'Amico, a longtime youth coach in town.

University of Connecticut psychologist Julian Ford, who spent time counseling in Newtown in the first days after the shooting, said it's important for the grieving process to include an outlet that lets children know that while things will never be the same, it's OK to enjoy life.

"They are all going to be thinking about what happened," he said. "That, unfortunately, is inescapable. But this gives them a chance to say, `Life is carrying on.' Nothing will be the same, but it's also continuing in ways that it should be."

Some students and their parents on Thursday toured the Chalk Hill school in Monroe, a former middle school being reopened next week for the Sandy Hook students. An open house is planned for Wednesday.

"Getting back into the school is like getting back on the horse," Robinson said. "Some of the scariness is gone once they cross that threshold. They are just so happy to see their teachers."

State police said they plan to keep their contact with the children to a minimum as they continue investigating the shooting.

"We certainly don't want to traumatize them any more than they've already been traumatized," said Lt. J. Paul Vance, the department's spokesman. "If (an interview is) not necessary it won't be done. Our investigators will make all those determinations."

In the meantime, Ford has encouraged parents to keep the kids involved in a normal holiday routine and deal with the tragedy as it comes up, rather than making it a focal point of their lives.

David Connors, who has 8-year-old triplets who attend Sandy Hook, said he and his wife have made play dates with their friends, brought the kids to see family for the holidays and participated in the class get-togethers and recreation events.

"That's been, I think, helpful at least in the short term just to kind of keep them doing things, keep them seeing their friends and being nearby and talking to family," Connors said.

Todd Wood of Newtown has five children, the youngest age 4 and the oldest in college. His children's piano teacher lost a child in the shooting, and the family knows other victims as well.

He said he's found that each child has reacted differently to the tragedy. He said he is not making the shooting the center of his family's life but is not pretending it didn't happen, either.

"We did Christmas, we had our lights here, we've tried to make things as normal as possible," he said. "But we also went down to see the memorials. I don't want to shield them from it. I want to let them grieve in their own way."

Ford said that is healthy. He said children will remember their friends as they go about doing normal kid things.

Chris Wolcott, the sport's academy's operations manager, said the best part of having the kids at the center is that the tragedy is pushed aside, at least for a little while.

"A couple times someone would drop a weight (in the facility's health center) and you would hear a bang and there would be a kid who would freeze for a second," he said. "But that would last a split-second. Most of the time, everyone just had a great time."

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Gen. 'Stormin' Norman Schwarzkopf Dead at 78













H. Norman Schwarzkopf, the retired general credited with leading U.S.-allied forces to a victory in the first Gulf War, died today at age 78.


The man who Defense Secretary Leon Panetta today called "one of the great military giants of the 20th century" died in Tampa, Fla., where he lived in retirement, the Associated Press reported.


Schwarzkopf, called "Stormin' Norman" because of his reportedly explosive temper, led America to two military victories: a small one in Grenada in the 1980s and a big one as de facto commander of allied forces in the Gulf War in 1991.


"'Stormin' Norman' led the coalition forces to victory, ejecting the Iraqi Army from Kuwait and restoring the rightful government," read a statement by former Secretary of State Colin Powell, who was chairman of the Joint Chiefs of Staff during the Gulf War. "His leadership not only inspired his troops, but also inspired the nation."


WATCH: Gen. Norman Schwarzkopf to Saddam Hussein: 'Get Outta Town'


Schwarzkopf's success during that fight, also known as Operation Desert Storm, came under President George H.W. Bush, who through his office today mourned "the loss of a true American patriot and one of the great military leaders of his generation."


"Gen. Norm Schwarzkopf, to me, epitomized the 'duty, service, country' creed that has defended our freedom and seen this great nation through our most trying international crises," Bush said. "More than that, he was a good and decent man -- and a dear friend."








Gen. Norman Schwarzkopf to Saddam Hussein: 'Get Outta Town' Watch Video









Gen. Schwarzkopf's '5 Minutes of Unimportant Questions' Watch Video









George H.W. Bush Hospitalized in ICU After 'Setbacks' Watch Video





Bush's office released the statement though the former president, himself, was ill, hospitalized in Texas with a stubborn fever and on a liquids-only diet.


The current White House occupant, President Obama, also memorialized Schwarzkopf, declaring him "an American original" who "stood tall for the country and Army he loved."


The future four-star general was born Aug. 24, 1934, in Trenton, N.J.


Schwarzkopf's father, who shared his name, directed the investigation of the Lindbergh baby kidnapping as head of the New Jersey State Police, later becoming a brigadier general in the U.S. Army.


Schwarzkopf was raised as an army brat in Iran, Switzerland, Germany and Italy, following in his father's footsteps to West Point, earning an engineering degree and being commissioned as a second lieutenant in 1956.


WATCH: Gen. Schwarzkopf's '5 Minutes of Unimportant Questions'


He earned three Silver Stars for bravery during two tours in Vietnam, gaining a reputation as an opinionated, plain-spoken commander with a sharp temper who would risk his own life for his soldiers.


"He had volunteered to go to Vietnam early just so he could get there before the war ended," said former Army Col. William McKinney, who knew Schwarzkopf from their days at West Point, according to ABC News Radio.


In 1983, as a newly-minted general, Schwarzkopf once again led troops into battle in President Reagan's invasion of Granada, a tiny Caribbean island where the White House saw American influence threatened by a Cuban-backed coup.


But he gained most of his fame in Iraq, where he used his 6-foot-3, 240-pound frame and fearsome temper to drive his forces to victory.


"He was known as a soldier's general," said retired Maj. Gen. Donald Shepperd, as he explained the "Stormin' Norman" nickname to ABC News Radio. "In other words, he really liked the troops and was soft on the troops. But boy, on his general officers, his officers, his NCO's, he was very, very tough and he had a real quick temper."


PHOTOS: In Memoriam: People We Lost in 2012


Gruff and direct, Schwarzkopf said during the Gulf War that his goal was to win the war as quickly as possible and with a focused objective: getting Iraq out of Kuwait.






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Mental illness, poverty haunted Afghan policewoman who killed American


KABUL (Reuters) - The Afghan policewoman suspected of killing a U.S. contractor at police headquarters in Kabul suffered from mental illness and was driven to suicidal despair by poverty, her children told Reuters on Wednesday.


The woman was identified by authorities as Narges Rezaeimomenabad, a 40-year-old grandmother and mother of three who moved here from Iran 10 years ago and married an Afghan man.


On Monday morning, she loaded a pistol in a bathroom at the police compound, hid it in her long scarf and shot an American police trainer, apparently becoming the first Afghan woman to carry out such an attack.


Narges also tried to shoot police officials after killing the American. Luckily for them, her pistol jammed. Her husband is also under investigation.


Her son Sayed, 16, and daughter Fatima, 13, described how they tried to call their parents 100 times after news broke of the shooting, then waited in vain for them to come home.


They recalled Narges's severe mood swings, and how at times she beat them and even pulled out a knife. But the children said she was consistent in bemoaning poverty.


"She was usually complaining about poverty. She was complaining to my father about our conditions. She was saying that my father was poor," Sayid said in an interview in their damp, cold two-room cement house.


On the floor beside him were his mother's prescriptions and a thick plastic bag filled with pills she tried to swallow to end the misery about a month ago. On another occasion, she cut her wrist with a razor, Sayed said.


"My father was usually calm and sometimes would say that she was guilty too because it wasn't a forced marriage. They fell in love and got married."


There was no sign in their neighborhood of the billions of dollars of Western aid that have poured into Afghanistan since the ouster of the Taliban in 2001, or of government investment.


RAW SEWAGE, STAGNANT WATER, DIRT ROADS


The lane outside their home stank of raw sewage.


Dirty, stagnant water filled holes in dirt roads nearby, where children in tattered clothes played and butchers stood by cow's hooves in shops choked by dust.


Afghanistan is one of the world's poorest nations, with a third of its 30 million residents living under the poverty line.


The sole distractions from the daily grind appeared to be a deck of playing cards and a compact disc with songs from Iranian pop singers, scattered on the floor of a room where Narges would lock herself in and weep, or sit in silence.


At times, Narges would try to focus on building her children's confidence, telling them to be guided by the Muslim holy book, the Koran, to tackle life's problems.


Sayed and Fatima said she never spoke badly of the U.S. presence in Afghanistan or of President Hamid Karzai's government.


Neighbor Mohammad Ismail Kohistani was dumbfounded to hear on the radio that Afghan officials were combing Narges' phone records to try to determine whether al Qaeda or the Taliban could have brainwashed her into carrying out a mission.


But he was acutely aware of her mental problems and often heard her scream at her husband, whose low-level job in the crime investigation unit of the police brought home little cash.


Kohistani, who operates a small sewing shop with battered machines, never imagined his neighbor could be accused of a high-profile attack that raised new questions about the direction of an unpopular war.


"I became very depressed and sad," said Kohistani, sitting on the floor few feet from a tiny wood-burning stove in Narges's home, alongside family photographs and a police training manual.


Fatima would often seek refuge in Kohistani's house when her mother's behavior became unbearable. "She did not hate us, but usually she was angry and would not talk to us," said Fatima, her eyes moist with tears.


Nevertheless, she missed her mother. The children were staying with a cousin.


"I ask the government to free my mother, otherwise our future will be destroyed," said Fatima.


Officials described it as another "insider shooting", in which Afghan forces turn on Westerners they are meant to be working with to stabilize the country. There have been over 52 such attacks so far this year.


The shooting at the police headquarters may have alarmed Afghanistan's Western allies. But some Afghans have grown numb to the violence.


Kohistani's 70-year-old father Omara Khan, who sports a white beard, sat twirling prayer beads beneath a photograph of Narges in a black veil beside one of her husband.


Asked what he thought of the attack, he laughed.


"This is common in Afghanistan," said Khan, who lived through decades of upheaval, including the 10-year Soviet occupation and a civil war that destroyed half of Kabul and killed some 50,000 civilians.


"People are killed every day."


(Editing by Ron Popeski)



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Indian rape victim arrives in S'pore for further treatment






SINGAPORE: An Indian student who was left fighting for her life after being gang-raped in New Delhi has arrived at Singapore's Mount Elizabeth Hospital for further treatment.

The patient arrived at the hospital's Intensive Care Unit at 9.05am in extremely critical condition, said the hospital's spokesperson on Thursday.

The hospital is working with the Indian High Commission, and has requested that the privacy of the patient and the family be respected.

The 23-year-old, whose attack sparked protests across India, had been transferred from the Safdarjung hospital in central Delhi to Medanta hospital in Gurgaon, close to the city's international airport, before being flown to Singapore.

"The decision was taken this morning at cabinet," a source at Safdarjung told AFP early Thursday. "Her mother and father are with her."

The government had earlier announced it was setting up a special commission of inquiry after the gang-rape on December 16 when the woman was allegedly tricked into boarding a bus by six men who then took turns to assault her.

The group also attacked her with an iron bar before throwing her out of the vehicle, along with a male companion.

Six suspects have been arrested in connection with the attack and have been remanded in custody.

- CNA/AFP/al



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Tap Twitter, control a cockroach





Too bad we can't control all cockroaches through Twitter. Yuck.



(Credit:
Brittany Ransom)


Next time you see a cockroach, don't scurry away faster than it can flee. In fact, if you're a lover of the weirder side of life, the intrusive insect could represent one heck of a science project.


For example, artist Brittany Ransom created Twitter Roach -- a discoid cockroach that can be controlled through tweets that it receives on the popular microblogging service.




As it turns out, humans can actually control cockroaches with a device called RoboRoach -- a tiny electronic backpack that attaches to a cockroach and stimulates the bug's antenna nerves, enabling the controller to turn the insect left or right with the press of a button.


Ransom built upon the Roboroach concept and added some Arduino hardware and custom-programmed software to link the bug to Twitter. While on display at the "Life, in some form" art exhibition by the Chicago Artists Coalition, visitors could send the @TweetRoach account commands such as "#TweetRoachLeft" and #TweetRoachRight."





The Tweet Roach sits while awaiting its next command.



(Credit:
Brittany Ransom)



Those of you concerned about insect welfare can rest easy; the roach didn't stay enslaved all day long. Ransom told Crave via e-mail that the bug "wears the backpack for short intervals" and "is only accessible to the Twitter community during designated times." To avoid a flood of commands, Ransom set the cockroach to receive no more than one tweet every 30 seconds.


Why would someone take on such a strange project? Ransom says she's exploring a kind of insectoid parallel to the digital overstimulation many of us experience today. She aims to see if the cockroach can learn to eventually learn to adapt and ignore the stimulating effects of her setup.


"At what point does its intelligence and ability take over? How much does it take before we are all desensitized to overstimulation? As we, as human beings, grow more cyborgian and interconnected through social media, this project helps us participate in discovering the answer," Ransom said in an e-mail about the project.



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Study: Cancer drug substitute linked to higher rate of relapse

(CBS News) Abby Alonzo was 10 when she was diagnosed in 2009 with Hodgkin's lymphoma, a cancer of the immune system. With proper treatment, 90 percent of patients survive.

"It wasn't as hard for me as I think it as it was on my mom and my brother and my dad," Abby says.

Abby began a seven-drug regimen. But in 2010, doctors told Abby's mother, Katie, there was a nationwide shortage of one of the medicines -- mechlorethamine.

"I started to get a little hysterical, 'Why is it not available?'" says Katie.

In 2010, 23 cancer drugs had shortages. Reasons include manufacturing problems and low profit margins for the drugs, which became mostly generic, and therefore less expensive, than brand-name.

"There is really nothing you can do," Katie says. "You do what your doctor tells you to do, you take what medications your doctor tells you to take, and you pray that it works. And if one of those medications isn't available, you just take, you know, the next-best thing."

Doctors thought the next-best thing for patients like Abby was a drug called cyclophosphamide.

Life-saving cancer drugs for children stuck in federal legislative limbo

But a new study in the New England Journal of Medicine showed 88 percent treated with the original drug were cancer-free after two years -- compared to only 75 percent of those receiving the replacement drug.

"This is the first study to clearly show that when we substitute one drug for what we think is just an equally good drug, that's not always going to be the case. So it's demonstrating a negative impact on patients," says Dr. Richard Gilbertson, the director of cancer care at St. Jude Children's Research Hospital.

Abby was one of the patients who relapsed. She then needed a bone marrow transplant, radiation and more chemotherapy. Right now, she shows no signs of cancer.

"What if I relapsed again? Or what if something else happens? You know, it is just really scary, that part," Abby says.

The original drug in the study is finally available again after almost three years. But there are still 13 drugs used in cancer therapy, and a total of 100 on the FDA shortage list.

Congress passed legislation last July giving the FDA more authority to deal with cancer drug shortages. That new law has made a big difference, and the key provision is the requirement that drug manufacturers let the FDA know when there's an impending shortage.

Since that law was passed, there has been a doubling of those notifications, so the FDA can increase imports from abroad and tell other manufacturers in the United States to step up production.

Another provision in that law is that the FDA set up a task force looking at other possible solutions to the drug shortage crisis, and they're required to submit that report to Congress by this coming July.

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Toyota Agrees to $1B Settlement in Acceleration Case












Toyota has agreed to pay more than $1 billion to customers to settle a class action lawsuit that alleged its vehicles accelerated dangerously and without warning, according to statements by the carmaker and the plaintiffs' attorney.


The deal, which still needs approval by a federal judge in California, includes a $250 million fund to be paid to Toyota owners who sold their cars at a loss following reports of vehicle malfunctions, as well as the installation of a brake override system in about 3.25 million vehicles


An additional $250 million fund will be created to pay those owners whose vehicles are not eligible for the retrofitted brakes.






David Zalubowski/AP PHoto







Toyota recalled more than 14 million vehicles after reports of sudden, unexplained acceleration in several models began to surface between 2009 and 2010. There were also reports of brake problems with the Prius hybrid.


Toyota insists that it was not an electrical flaw that caused the acceleration problems, but driver error, floor mats and sticky gas pedals.


Both the National Highway Traffic Safety Administration and NASA have said there is nothing in wrong with programs that run the vehicles' onboard computers


"From the very start, this was a challenging case," said Steve Berman, the plaintiffs' lawyer. "We brought in automotive experts, physicists and some of the world's leading theoreticians in electrical engineering to help us understand what happened to drivers experiencing sudden acceleration."


The settlement also includes $30 million to be given to outside groups to study automotive safety.


In a statement, Toyota agreed to the deal.


"In keeping with our core principles, we have structured this agreement in ways that work to put our customers first and demonstrate that they can count on Toyota to stand behind our vehicles." said Toyota spokesman Christopher P. Reynolds.



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